Ordinary colorectal cancers expressing synaptophysin: Myth or reality?

#4070

Introduction: Despite the neuroendocrine differentiation in CRCs has been extensively assessed, currently there are no established criteria for inclusion for this designation.

Aim(s): We aimed to explore whether a variable neuroendocrine differentiation in ordinary colorectal cancer (CRCs) without a suggestive morphology is of clinical relevance.

Materials and methods: We tested 663 ordinary CRCs with a non-neuroendocrine morphology for synaptophysin expression (Syn) and correlated the results with clinicopathological characteristics and molecular profile, as well as patient survival, and compared the survival characteristics of syn expression group to those of ordinary CRCs and additionally to those of pure 14 mixed adeno-neuroendocrine carcinomas (MANECs).

Conference:

Presenting Author:

Authors: Sabella G,

Keywords: neuroendocrine, MANEC, synapthophysin,