Abstract Library

#3910 Integrative molecular analysis of lung neuroendocrine neoplasms with different Ki-67 indices identifies a molecular transition group between low- and high-grade neoplasms

Introduction: In the 2021 World Health Organization (WHO) classification of lung cancers, lung neuroendocrine neoplasms (LNENs) are classified as low-grade, intermediate-grade and high-grade based on mitotic count but not Ki-67 index, as for GEP-NENs.

Conference:

Presenting Author:

Authors: Simbolo M, Centonze G, Ali G, Grillo F, Sabella G,

Keywords: lung neuroendocrine tumor, NET grade 3, next generation sequencing, transcriptomics,

#3733 New insights on the clinical role of Ki-67 and spindle cell and oncocytic histological variants in lung carcinoid tumors

Introduction: WHO classification defines lung carcinoid tumors (LCTs) as well-differentiated neuroendocrine neoplasms classified in typical (TC) and atypical carcinoids (AC). Morphologic factors and protein expression able to predict recurrence after surgical curative resection are little known. Ki-67 and spindle cell and oncocytic histological variants may impact on differential diagnosis, but their clinical relevance is much debated.

Conference:

Presenting Author: Milione M

Authors: Centonze G, Maisonneuve P, Grillo F, Prinzi N, Lagano V,

Keywords: lung carcinoid, Ki-67, spindle cell, oncocytic, Immunohistochemistry,

#3468 Novel morphological tools in predicting pancreatic neuroendocrine tumors (Pan-Net) clinical outcome

Introduction: Pancreatic Neuroendocrine Tumor (Pan-NET) clinical outcome shows a high variability among patients within the same World Health Organization (WHO) category. To date, there is a lack of markers to predict recurrence after resection, which makes it difficult to identify patients with higher risk of progression.

Conference:

Presenting Author:

Authors: Lagano V, Sabella G, Cattaneo L, Grillo F, Mangogna A,

Keywords: Pancreas, parenchymal infiltration, tumor deposits,

#3409 Ascl1 and OTP identify four prognostic groups among atypical carcinoids

Introduction: Atypical Carcinoids (AC) according World Health Organization guidelines are well differentiated Lung Neuroendocrine tumor with 2-10 mitoses/2 mm2 and/or with necrosis. Besides morphological differentiation no further tools in predicting AC clinical outcome are proposed.

Conference:

Presenting Author:

Authors: Centonze G, Maisonneuve P, Grillo F, Mangogna A, Prinzi N,

Keywords: Atypical Carcinoid, lung, ascl1, otp,

#3347 Broncho-pulmonary combined large-cell neuroendocrine carcinomas (Co-LCNEC): More than a hybrid neoplasm

Introduction: The current WHO classification of lung neoplasms defines combined large cell neuroendocrine carcinomas (CoLCNECs) as the association of an LCNEC with a recognizable component of adenocarcinoma, squamous cell carcinoma, small cell carcinoma or, rarely, with atypical carcinoid.

Conference:

Presenting Author:

Authors: Simbolo M, Centonze G, Giudice L, Ciaparrone C, Grillo F,

Keywords: neuroendocrine carcinoma, combined large cell neuroendocrine carcinoma, next generation sequencing, transcriptomics,