New insights on the clinical role of Ki-67 and spindle cell and oncocytic histological variants in lung carcinoid tumors

#3733

Introduction: WHO classification defines lung carcinoid tumors (LCTs) as well-differentiated neuroendocrine neoplasms classified in typical (TC) and atypical carcinoids (AC). Morphologic factors and protein expression able to predict recurrence after surgical curative resection are little known. Ki-67 and spindle cell and oncocytic histological variants may impact on differential diagnosis, but their clinical relevance is much debated.

Aim(s): Identify novel factors able to predict LCTs disease aggressiveness and progression.

Materials and methods: Morphology and immunohistochemical markers (Ki-67, TTF1, OTP, Sstr2a, Ascl1, p53 and Rb1) on a multicentre histological revaluated series of 297 TCs and 58 ACs were studied and correlated with overall survival (OS), cancer-specific survival (CSS) and disease-free survival (DFS).

Conference:

Presenting Author: Milione M

Authors: Centonze G, Maisonneuve P, Grillo F, Prinzi N, Lagano V,

Keywords: lung carcinoid, Ki-67, spindle cell, oncocytic, Immunohistochemistry,