Ascl1 and OTP identify four prognostic groups among atypical carcinoids

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Introduction: Atypical Carcinoids (AC) according World Health Organization guidelines are well differentiated Lung Neuroendocrine tumor with 2-10 mitoses/2 mm2 and/or with necrosis. Besides morphological differentiation no further tools in predicting AC clinical outcome are proposed.

Aim(s): Identify novel factors able to predict AC disease aggressiveness and progression.

Materials and methods: 370 lung carcinoids from several hospitals were collected and centrally reviewed by three experienced pathologists. Immunohistochemistry (IHC) was performed for Ki-67, TTF-1, CD44, OTP, Sstr2a, Ascl1, p53 and Rb. Morphologic and IHC data were correlated with Overall Survival (OS) and Disease-free Survival (DFS).

Conference:

Presenting Author:

Authors: Centonze G, Maisonneuve P, Grillo F, Mangogna A, Prinzi N,

Keywords: Atypical Carcinoid, lung, ascl1, otp,