Abstract Library

#4175 Immunohistochemical profiling of lung carcinoid subtypes and marker comparison of matched primary and metastatic tumors

Introduction: Multi-omic studies have identified three lung carcinoid (LC) subtypes (A1, A2, B) with unique gene expression for OTP, ASCL1 & HNF1a.

Conference:

Presenting Author: Leunissen D

Authors: Leunissen D, Moonen L, von der Thüsen J, den Bakker M, Hillen L,

Keywords: lung carcinoid, TTF1, S100, metastatic disease,

#3886 Large cell neuroendocrine carcinoma subtyping based on NEUROD1, ASCL1, POU2F3 and YAP1 expression

Introduction: Large cell neuroendocrine carcinoma (LCNEC) accounts for 1-3% of all types of lung cancer and is, similar to small-cell lung cancer (SCLC), a high-grade tumor with poor prognosis. pRb can also be used to subclassify LCNEC into SCLC-like and NSCLC-like. SCLC can be classified in 4 transcriptomic subtypes (NEUROD1high, ASCL1high, POU2F3high, YAP1high), which may have therapeutic implications. It is unclear whether these subtypes are also found in LCNEC and if they correlate with pRb expression.

Conference:

Presenting Author: Heijboer F

Authors: Rijnsburger N, Heijboer F, Derks J, Hermans B, Hillen L,

Keywords: LCNEC, pulmonary, immunohistochemistry, pathology, pRb, transcription factors,

#3854 Protein validation of multi-omic classified pulmonary carcinoid – Identification of unique clinical subtypes and potential therapeutic vulnerability

Introduction: Multi-omic studies have identified three pulmonary carcinoid (PC) subtypes (A1, A2, B) with unique expression for OTP, ASCL1 & HNF1a.

Conference:

Presenting Author: Derks J

Authors: Derks J, Moonen L, Leunissen D, von der Thüsen J, den Bakker M,

Keywords: lung carcinoid, biomarker, molecular profile, OTP, ASCL1, HNF1a,

#3733 New insights on the clinical role of Ki-67 and spindle cell and oncocytic histological variants in lung carcinoid tumors

Introduction: WHO classification defines lung carcinoid tumors (LCTs) as well-differentiated neuroendocrine neoplasms classified in typical (TC) and atypical carcinoids (AC). Morphologic factors and protein expression able to predict recurrence after surgical curative resection are little known. Ki-67 and spindle cell and oncocytic histological variants may impact on differential diagnosis, but their clinical relevance is much debated.

Conference:

Presenting Author: Milione M

Authors: Centonze G, Maisonneuve P, Grillo F, Prinzi N, Lagano V,

Keywords: lung carcinoid, Ki-67, spindle cell, oncocytic, Immunohistochemistry,

#3409 Ascl1 and OTP identify four prognostic groups among atypical carcinoids

Introduction: Atypical Carcinoids (AC) according World Health Organization guidelines are well differentiated Lung Neuroendocrine tumor with 2-10 mitoses/2 mm2 and/or with necrosis. Besides morphological differentiation no further tools in predicting AC clinical outcome are proposed.

Conference:

Presenting Author:

Authors: Centonze G, Maisonneuve P, Grillo F, Mangogna A, Prinzi N,

Keywords: Atypical Carcinoid, lung, ascl1, otp,