The role of metabolism in neuroendocrine tumour cell models and patients

#4531

Introduction: It is recognised that the adipose tissue plays a major role in cancer through a metabolic coupling that supports tumour cell growth. Recent evidence suggests that altered metabolic pathways drive the development and influence the clinical outcomes of gastroenteropancreatic neuroendocrine tumours (GEP-NETs).

Aim(s): This study aims to explore the role of metabolism in NET cell models and patients.

Materials and methods: A retrospective study was conducted on 23 GEP-NET patients (11 ileal and 13 pancreatic). RNA-sequencing analysis was performed according to patient body mass index (BMI) (high BMI: >25; low BMI:

Conference:

Presenting Author: Calabrese C

Authors: Calabrese C, Dellavalle S, Miserocchi G, Gabellone S, Spadazzi C,

Keywords: tumour metabolism, adipocytes, RNA-sequencing, GEP-NET,