Abstract Library

#1202 Role of Amplifications in the PIK3/Akt/mTOR-Pathway in Neuroendocrine Tumors of the Small Intestine

Introduction: Amplifications in the PIK3/Akt/mTOR pathway can lead to increased proliferation and reduced apoptosis, resulting in the development of various cancers. Recently, amplifications of Akt1/2, PDGFRα/β and mTOR in small intestine neuroendocrine tumors (siNET) have been shown.

Conference: 12th Annual ENETSConcerence (2015)

Presenting Author:

Authors: Hoffmeister M, Sperveslage J, Anlauf M, Petersen K, Gress T,

Keywords: NET, gene amplification, mTOR pathway,

#1167 Cowden Syndrome and Concomitant Pulmonary Neuroendocrine Tumor: A Presentation of Two Cases

Introduction: Cowden Syndrome is a multiorgan disorder with germline mutations in the tumor suppressor gene PTEN leading to dysfunctional cell growth and risk of neoplasms in e.g. breast and thyroid, but no association with NET has been described.

Conference: 12th Annual ENETSConcerence (2015)

Presenting Author: Ringholm L

Authors: Ringholm L, Langer S, I Dali C, Petersen R, Rasmussen A,

Keywords: Cowden Syndrome, pulmonary NET,

#730 Loss of Chromosome 18 in Neuroendocrine Tumors of the Midgut

Introduction: The genetic alterations in neuroendocrine tumors (NET) of the midgut, in particular of the appendix (aNET), are poorly characterized. The most frequent chromosomal aberration in ileal NET (iNET) is the loss of one chromosome 18. The relevance of this alteration is unclear.

Conference: 10th Annual ENETSConcerence (2013)

Presenting Author:

Authors: Henopp T, Brix J, Sperveslage J, Anlauf M, Petersen K,

Keywords: chr18,

#700 Comparative Expression Analysis of Chromosome 18 Related miRNAs in Ileal NET with and without Chr18 Loss

Introduction: MicroRNAs (miRs) play important roles in many kinds of biological processes. Because the (partial) loss of one chromosome 18 (Chr18) is a frequent event in ileal NETs (iNETs), we assessed the potential deregulation of miR-expression in these patients.

Conference: 10th Annual ENETSConcerence (2013)

Presenting Author: Sperveslage J

Authors: Hoffmeister M, Sperveslage J, Henopp T, Anlauf M, Petersen K,

Keywords: NET, mir-expression,

#562 Expression of Chromosome 18 Related Tumor Suppressor Proteins in Ileal Neuroendocrine Tumors

Introduction: The genetic alterations in ileal neuroendocrine tumors (iNETs) are poorly characterized. The most frequent chromosomal aberration is the loss of one chromosome 18 in iNETs, however, the relevance of this alteration is unclear.

Conference: 9th Annual ENETSConcerence (2012)

Presenting Author:

Authors: Henopp T, Brix J, Sperveslage J, Anlauf M, Petersen K,

Keywords: chromosome 18, ileal NET, neuroendocrine,