Expression of Chromosome 18 Related Tumor Suppressor Proteins in Ileal Neuroendocrine Tumors

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Introduction: The genetic alterations in ileal neuroendocrine tumors (iNETs) are poorly characterized. The most frequent chromosomal aberration is the loss of one chromosome 18 in iNETs, however, the relevance of this alteration is unclear.

Aim(s): In this study, we investigated the status of chromosome 18 and the expression of chromosome 18 related tumor suppressor proteins in stage stratified cohorts (N0M0, N1M0 and N1M1) of iNETs, in order to identify tumor progression factors.

Materials and methods: The loss of chromosome 18 was examined using fluorescence in situ hybridization in 77 primary iNETs. The expression of tumor suppressor proteins Smad2, Smad4, Maspin and DCC was assessed by immunohistochemistry. Tumor suppressors were also stained in normal endocrine cells by immunofluorescence double labelling.

Conference: 9th Annual ENETSConcerence (2012)

Presenting Author:

Authors: Henopp T, Brix J, Sperveslage J, Anlauf M, Petersen K,

Keywords: chromosome 18, ileal NET, neuroendocrine,