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#72 Reduced expression of p27 and the occurrence of CpG island methylator phenotype in insulinomas

Introduction: The molecular pathogenesis of sporadic insulinoma is unclear, though some of the genes were found to be slienced by promoter methylation. CpG island methylator phenotype (CIMP) was found in a number of common tumors and correlated with loss of expression of p27, which may contribute to the tumorigenesis of the tumors.

Conference: 7th Annual ENETSConcerence (2010)

Presenting Author: Chen Y

Authors: Chen Y, Zhou Q, Xiao Y, Zhu Y, Liu T,

Keywords: insulinoma, p27 gene, promoter methylation, CpG island methylator phenotype ,