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#66 Adrenocortical cancer: a therapeutic approach with everolimus (RAD001)

Introduction: Adrenocortical cancer (ACC) is a rare disease with very poor outcome. ACC responds poorly to standard chemotherapy. Mitotane, used as adjuvant therapy to surgery, prolongs recurrence-free survival, but the response is limited to 23% of patients and resistance occurs in the majority of patients (1). There is no curative therapy for ACC. Pre-clinical studies have shown involvement of both IGF-2/IGF-1R and Akt/mTOR pathways in ACC, and IGF-1R and mTOR inhibitors inhibited cell proliferation of human adrenocortical carcinoma cell lines in vitro (2,3,4).

Conference: 7th Annual ENETSConcerence (2010)

Presenting Author:

Authors: Gueorguiev M, Bhattacharya S, Grossman A,

Keywords: adrenocortical cancer, mTOR inhibitors, everolimus,