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#4209 Transcriptomic and spliceosomic landscapes of pancreatic neuroendocrine tumors generated through Oxford Nanopore Technology sequencing

Introduction: Pancreatic Neuroendocrine tumors (PanNETs) are rare neoplasms with heterogenous nature, still poorly understood. Their low mutational burden has prompted to explore other molecular aspects, from epigenomics to transcriptomics. Increasing evidence indicates that transcriptomic changes, often derived from alterations in alternative splicing, can generate isoforms with oncogenic potential. In this context, long-read Oxford Nanopore Technology (ONT) has emerged as an ideal suited sequencing tool to deeply study transcriptomics and splicing variants.

Conference:

Presenting Author: Moreno Montilla M

Authors: Moreno Montilla M, Jones G, Jeffries A, Blazquez Encinas Rey R, Bamford R,

Keywords: Pancreatic Neuroendocrine Tumor, Oxford Nanopore Technology Sequencing, Transcriptomics, Splicing, Fusion Genes,