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#629 Targeting Chaperone Activity and Chaperone Expression in Human GEP-NET Cells Can Repress Their Proliferation and Sensitize Them to Chemotherapy

Introduction: New approaches for better treatment of gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are acutely needed. Inhibitors of chaperone activity of heat shock protein 90 (Hsp90) seem to be promising agents but they upregulate cytoprotective chaperones Hsp70 and Hsp27.

Conference: 10th Annual ENETSConcerence (2013)

Presenting Author:

Authors: Demidkina A, Kudryavtsev V, Mosina V, Kabakov A,

Keywords: chemosensitization, heat shock protein, 17AAG,