Abstract Library

#1305 PRRT for Malignant Pheochromocytomas and Paragangliomas: The Singapore General Hospital Experience

Introduction: In recent years, the use of 177Lu-DOTATATE radioisotope therapy has been expanded to patients with metastatic pheochromocytomas and paragangliomas (PCC/PGL). Although this is not the standard of care, treatment options are limited for those with MIBG negative disease. Our centre has treated over 40 patients with NETS with PRRT since 2012.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author:

Authors: Loh L, Lim D, Loke K, Ng D,

Keywords: PRRT, pheochromocytoma, paraganglioma,

#362 Succinate Dehydrogenase (SDH) Complex Expression in Pancreatic Endocrine Tumours (PETs)

Introduction: Absence of SDH subunit D (SDHD) mutations were reported by Perren et al (Oncogene 2002) but loss of heterozigosity (LOH) was described in 29% of the PETs. Since SDHD gene may depict a form of genomic imprinting in neuroendocrine (NE) tissue, the reported LOH may drive activation of the hypoxia pathway. Taking advantage from the immunohistochemical (IHC) method for genetic triage we may deduce the mutational status of SDH subunits (A, B, C and D) based on IHC SDHB expression. These subunits are striking candidates as they are mutated in other NE neoplasias.

Conference:

Presenting Author:

Authors: Vinagre J, Preto J, Soares P, Lopes J,

Keywords: PETs SDH LOH,

#264 Alterations of TIMP-3 Gene in Insulinomas and Its Significance

Introduction: Our previous study on insulinoma found allelic loss of 22q12 where suppressor gene TIMP3 located. TIMP3 can inhibit tumor invasion or metastasis, but its clinical implications in insulinoma are unknown.

Conference: 8th Annual ENETSConcerence (2011)

Presenting Author:

Authors: Chen Y, Zhou C, Wu H, Liu T, Xiao Y,

Keywords: insulinoma, TIMP-3 gene, allelic loss, biomarker,

#212 Reduced MEN1 Gene Expression in Pulmonary Carcinoids Is Associated With Metastatic Disease

Introduction: Lung carcinoids are neuroendocrine tumors that can be classified as typical (TC) or atypical (AC) carcinoids. Previously, MEN-1 mutations and associated LOH of 11q13 have been implied in tumorigenesis.

Conference: 8th Annual ENETSConcerence (2011)

Presenting Author:

Authors: Swarts D, Henfling M, Ramaekers F, Van Suylen R, Dingemans A,

Keywords: bronchial carcinoids, methylation specific PCR, multiple endocrine neoplasia type 1, hypermethylation,

#122 Molecular genetic findings in gastric carcinoid suggest possible neurofibromin/Ras pathway involvement in carcinoid pathogenesis

Introduction: The molecular pathogenesis of gastrointestinal carcinoid tumours is poorly understood. We have been undertaking molecular genetic investigations of a young woman with neurofibromatosis type 1 (NF1) in whom a gastric carcinoid tumor was detected following an episode of gastrointestinal bleeding. She was otherwise relatively mildly affected by NF1. In NF1, gastric carcinoids have been found previously only in patients with other predisposing factors, which were absent in this patient.

Conference: 7th Annual ENETSConcerence (2010)

Presenting Author: Tobias E

Authors: Tobias E, Fletcher A, Cooke A, Traynor J, Onen N,

Keywords: gastric carcinoid, neurofibromatosis, NF1, LOH, genetic, Ras,