Abstract Library

#4510 Follow-up analysis of group nutritional education in patients with neuroendocrine neoplasms (GEDNEN Course): A novel approach with proven acceptability

Introduction: Structured group education demonstrates improved outcomes in peri-operative health optimisation and diabetes mellitus. We devised and delivered a novel in person nutrition/dietary education programme for patients with neuroendocrine neoplasms (NENs) at the Sheffield ENETS Centre of Excellence.

Conference:

Presenting Author: Munir A

Authors: Wen Loh E, Walsh E, Bisson H, Ahmed Z, Dancyger-Stevens L,

Keywords: Group Education, Nutrition, Neuroendocrine Neoplasm, Novel Tool,

#4157 Decoding and targeting of metabolic heterogeneity in pancreatic neuroendocrine tumors (PanNETs): MCT1 and MCT4 in the crosshair for precision therapy

Introduction: Mechanisms driving progression from indolent to aggressive and metastatic disease in PanNET are largely unknown. Recent transcriptome and epigenome analyses suggest a stepwise progression model leading to enhanced proliferation, de-differentiation, and metabolic reprogramming. However, the metabolic landscape at different stages and the therapeutic potential of targeting metabolic proteins remain largely uncharacterized.

Conference:

Presenting Author: Sadowski M

Authors: Bräutigam K, Straub J, Bihi A, Andreasi V, Kirchner P,

Keywords: metabolic heterogeneity, 3D model, precision medicine, metabolic subtype, PanNET, hypoxia, lactate efflux, microvessel density, MCT1/MCT4,

#4007 Inactivation of PHLDA3 gene leading to tumorigenesis of pancreatic neuroendocrine tumors and its molecular mechanisms

Introduction: The molecular mechanism underlying the tumorigenesis of sporadic pancreatic neuroendocrine tumors (PNETs) is largely unknown. Our previous studies showed that loss of heterozygosity (LOH) at chromosome 1q31 (including PHLDA3 gene) was frequently found in sporadic PNETs (2005 insulinoma and 2003 gastrinoma, respectively).

Conference:

Presenting Author: Song Y

Authors: Song Y, Tong W, Wang Z, Chen Y,

Keywords: pancreatic neuroendocrine tumor, PHLDA3, tumorigenesis, prognosis,

#3805 Transcriptomic analyses of multifocal ileal neuroendocrine tumors

Introduction: Small intestinal neuroendocrine tumors are mostly located in the distal ileum with a high incidence of multiple synchronous primary tumors. To date, loss of heterozygosity (LOH) at chr18 has been the most frequent genomic event identified, occurring in ~60% of tumors. Recently, we showed that synchronous primary tumors from the same ileal NET patient display distinct somatic mutational profiles, including distinct patterns of chr18 LOH, suggesting these tumors originate independently. Thus, new mechanistic insights into multifocal ileal NETs are urgently needed.

Conference:

Presenting Author:

Authors: Mäkinen N, Zhang Z, Munn S, Kasai Y, Kim G,

Keywords: Multifocal ileal NETs, RNA-sequencing, Gene expression,

#3392 The chromosome 18 loss of heterozygosity axis of small intestinal neuroendocrine tumors

Introduction: Small intestinal neuroendocrine tumors (siNETs) are rare neoplasms which have low mutational burdens: With subtypes characterised in terms of copy number variation (CNV). Subtypes are defined as: Chromosome 18 loss of heterozygosity (18LOH), multiple copy number variation (MultiCNV), or no copy number variations (NoCNV). 18LOH tumors are associated with improved outcomes, the reasons for which are poorly understood.

Conference:

Presenting Author: Waterfield S

Authors: Waterfield S, Yousefi P, Amaulu A, Relton C, Thirlwell C,

Keywords: neuroendocrine, small intestinal, methylation, epigenetics, omics,