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#122 Molecular genetic findings in gastric carcinoid suggest possible neurofibromin/Ras pathway involvement in carcinoid pathogenesis

Introduction: The molecular pathogenesis of gastrointestinal carcinoid tumours is poorly understood. We have been undertaking molecular genetic investigations of a young woman with neurofibromatosis type 1 (NF1) in whom a gastric carcinoid tumor was detected following an episode of gastrointestinal bleeding. She was otherwise relatively mildly affected by NF1. In NF1, gastric carcinoids have been found previously only in patients with other predisposing factors, which were absent in this patient.

Conference: 7th Annual ENETSConcerence (2010)

Presenting Author: Tobias E

Authors: Tobias E, Fletcher A, Cooke A, Traynor J, Onen N,

Keywords: gastric carcinoid, neurofibromatosis, NF1, LOH, genetic, Ras,