Abstract Library

#595 A Single Fasting Plasma 5-HIAA Value Correlates with 24-Hour Urinary 5-HIAA Values and Other Biomarkers in Midgut Neuroendocrine Tumors (NETs)

Introduction: 5-hydoxyindoleacetic acid (5-HIAA) is used for the evaluation of neuroendocrine tumors (NETs), however, the current 5-HIAA assay requires a 24-hour urine collection which is inconvenient.

Conference: 10th Annual ENETSConcerence (2013)

Presenting Author:

Authors: Tellez M, Mamikunian G, Go V, O'Dorisio T, Vinik A,

Keywords: 5 Hydroxyindoleacetic acid, 5-HIAA, neuroendocrine tumors, midgut, serotonin, carcinoid syndrome,

#386 A Prospective Evaluation of the Effects of Chronic Proton Pump Inhibitor Use on Plasma Biomarker Levels in Humans

Introduction: Proton pump inhibitors (PPIs) are used primarily to treat gastroesophageal reflux disease. PPI-induced achlorhydria increases circulating gastrin and chromogranin A (CGA). CGA is a widely used biomarker for the diagnosis and follow-up for gut-based neuroendocrine tumors (NETs). PPI-induced increases in CGA or gastrin may falsely suggest the presence of a NET when none exists. Pancreastatin, a fragment of CGA, is also commonly used to diagnose and follow NETs.

Conference: 9th Annual ENETSConcerence (2012)

Presenting Author:

Authors: Raines D, Chester M, Diebold A, Mamikunian P, Anthony C,

Keywords: Chromogranin A, gastrin, pancreastatin, neuroendocrine tumor (NET),