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#79 PTOV-1 overexpression in neuroendocrine tumors: a new molecular marker

Introduction: PTOV-1 (Prostate Tumor Overexpressed-1) is a novel protein encoded by 12-exon gene localized in chromosome 19q.13.3. Recently identified as an androgen-induced gene, it is involved in prostate cell proliferation and in prostate human cancer. PTOV-1 expression has been demonstrated in neuroendocrine cells of normal prostate tissue. Preliminary data indicate that PTOV-1 can be related to flotilin, integrins and other cellular factors involved in cancer progression.

Conference: 7th Annual ENETSConcerence (2010)

Presenting Author: Landolfi S

Authors: de Torres I, Castellvi J, Landolfi S, Fernandez S, Alaña L,

Keywords: PTOV-1, chromogranin A, NETs, inmunohistochemistry,