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#788 A Novel Animal Model for Medullary Thyroid Carcinoma

Introduction: Medullary thyroid carcinoma (MTC) is a neuroendocrine cancer originating from calcitonin-producing C-cells. Surgical resection is the most effective treatment currently available. Understanding the molecular pathways mediating MTC is crucial for the development of novel therapies. Cyclin-dependent kinase 5 (Cdk5) and its activators, p35 and p25, have recently been implicated in MTC etiology. P25 is a cleavage product of p35 and the binding of p25 to Cdk5 leads to aberrant Cdk5 activity.

Conference: 10th Annual ENETSConcerence (2013)

Presenting Author:

Authors: Pozo K, Castro-Rivera E, Tan C, Siegl V, Plattner F,

Keywords: thyroid, Cdk5,