Abstract Library

#3918 Efficiency of GemCap + mitotane in platinum and mitotane resistant adrenocortical carcinoma

Introduction: Gemcitabine, metronomic capecitabine and mitotane (M) combination (GemCap + M) is the most investigated and widely used regimen in 2nd and subsequent lines therapy of advanced adrenocortical cancer (ACC). In the largest retrospective study (N=145) only 28% of patients (pts) reached therapeutic concentration of mitotane (M), which translated into a significant improvement in the median progression free survival (PFS).

Conference:

Presenting Author: Zhulikov Y

Authors: Zhulikov Y, Kovalenko E, Bokhyan V, Evdokimova E, Khoroshilov M,

Keywords: adrenocortical cancer, gemcitabine, capecitabine, GemCap, mitotane,

#3916 Temozolomide as second and subsequent lines of treatment in metastatic adrenocortical cancer: Prospective phase II clinical trial

Introduction: Adrenocortical carcinoma (ACC) is a rare malignancy with limited treatment options. There are still no effective options for 2nd and subsequent lines of chemotherapy (ChT). Despite promising results of retrospective study with temozolomide (Tem), no prospective studies evaluating Tem efficacy have been published yet.

Conference:

Presenting Author: Zhulikov Y

Authors: Zhulikov Y, Kovalenko E, Bokhyan V, Khoroshilov M, Gabrava M,

Keywords: adrenocortical cancer, temozolomide, mitotane,

#3573 Treatment of advanced adrenocortical cancer (ACC): Data from 152 patients of the national and multicenter ICARO_GETHI/SEEN registry

Introduction: Adrenocortical carcinoma (ACC) is a rare tumor with a poor prognosis in stage IV with only one treatment regimen of chemotherapy (CT), etoposide, doxorubicin, and cisplatin (EDP) and mitotane with proven activity in a phase 3 trial.

Conference:

Presenting Author:

Authors: Álvarez-Escolá C, Ballester I, Garcia Donas J, Paja M, Iglesias C,

Keywords: Adrenocortical cancer, mitotane, chemotherapy, survival, registry,

#3562 Prognostic factors in stage I-III adrenocortical cancer (ACC): Data of 230 patients from the ICARO_GETHI/SEEN registry

Introduction: The scientific evidence on adjuvant treatment of adrenocortical carcinoma (ACC) is scarce and based on a retrospective Italian-German series.

Conference:

Presenting Author: Jimenez-Fonseca P

Authors: Ballester I, Álvarez-Escolá C, Valdes N, Hernando J, Picon M,

Keywords: Adrenocortical cancer, Adjuvant treatment, Mitotane, Prognosis, Survival,

#1163 Mitotane, Adrenolitic Drug, Inhibits Cell Survival and Function of Several Pituitary Cytotypes

Introduction: Mitotane (DDD) is an adrenolytic agent that is used for the treatment of adrenocortical carcinoma. We previously demonstrated that DDD affects thyrotrope cell viability and function. These data represent a possible explanation of the biochemical picture consistent with central hypothyroidism in patients undergoing DDD therapy. DDD also inhibits corticotrope cell viability by inducing caspase-mediated apoptosis and reduces POMC expression as well as basal and CRH-induced ACTH secretion. Cells originating from tissues different from pituitary are not sensitive to the inhibitory effects of DDD. Our data suggest that DDD inhibits cell survival and function of many pituitary cytotypes, acting with a generalized, but specific, toxic effect. The majority of male patients undergoing adjuvant DDD therapy show a clinical picture of hypogonadism, characterized by low free testosterone and unmodified LH concentration

Conference: 12th Annual ENETSConcerence (2015)

Presenting Author: Gentilin E

Authors: Gentilin E, Gagliano T, Benfini K, Di Pasquale C, Falletta S,

Keywords: mitotane, adrenocortical cancer, pituitary,