68Ga-DOTATOC PET and Gene Expression Profile in Patients with Neuroendocrine Carcinomas

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Introduction: Somatostatin receptor expression on both protein and gene expression levels were compared with in vivo 68Ga-DOTATOC PET/CT in patients with neuroendocrine carcinomas (NEC).

Aim(s): .

Materials and methods: Twenty-one patients with verified NEC who underwent a 68Ga-DOTATOC PET/CT between November 2012 and May 2014, were retrospectively included. By quantitative real-time polymerase chain reaction (qPCR) we quantitatively determined the gene expression of several genes and compared these with 68Ga-DOTATOC PET. By immunohistochemistry we qualitatively studied the expression of selected proteins in NEC.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author: Olsen I

Authors: Olsen I, Langer S, Federspiel B, Oxbøl J, Loft A,

Keywords: neuroendocrine carcinoma, gene expression, 68Ga-DOTATOC, IHC, SSTR2,