A complex and rare association of neuroendocrine and endocrine neoplasms: A case report

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Introduction: Neuroendocrine tumours (NETs) are sporadic or genetically inherited heterogenous neoplasms affecting multiple sites.

Aim(s): To present a case of a patient with multiple NETs and endocrine neoplasms.

Materials and methods: A 65-year-old woman was hospitalised for a psychotic episode with refractory hypokalaemia. Her medical history included transsphenoidal surgery for a pituitary corticotrophe adenoma, thyroidectomy for papillary microcarcinoma, schizophrenia, type 2 diabetes mellitus and hypertension. Given her Cushingoid habitus, hormonal and imaging studies were requested, leading to a diagnosis of Cushing’s disease (CD) from a recurrent ACTH-secreting pituitary adenoma. During hospitalisation a CT scan was performed due to pulmonary embolism, revealing lung nodules and left adrenal mass, confirmed by an MRI. On suspicion of pheochromocytoma, internal medicine colleagues requested adrenal scintigraphy with 123I-MIBG, showing increased uptake in the left adrenal lodge.

Conference:

Presenting Author: Cerroni L

Authors: Cerroni L, Filice A, Feola T, Sesti F, Vincenzi L,

Keywords: cushing disease, atypical carcinoid, ileal net, genetics,