A Nomogram Consisted of Routine Biochemical Tests May Increase the Diagnostic Accuracy of Chromogranin A in Detecting Patients with Neuroendocrine Tumors


Introduction: Serum chromogranin A (CgA) may be falsley increased in patients with renal impairment and systemic inflammation.

Aim(s): We aimed to investigate which laboratory parameters are independently associated with increased CgA and to develop a nomogram in order to improve the diagnostic accuracy of CgA in detecting patients with neuroendocrine tumors (NET).

Materials and methods: We included 155 subjects (controls) and 55 treatment naïve patients with NET, with available data on CgA, other laboratory tests, medical history and antropomethric parameters. Nomogram was developed in a form of scoring system, based on z-score obtained from receiver operating curve analysis for each parameter that was independently associated with CgA.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author: Kruljac I

Authors: Kruljac I, Petranović Ovčariček P, Gladić Nenadić V, Marić Brozić J, Dabelić N,

Keywords: Neuroendocrine tumor, chromogranin A, accuracy, sensitivity, specificity,

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