A patient derived organoid model of neuroendocrine neoplasms enables long-term growth in vitro of low grade tumors and reveals therapeutic vulnerabilities

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Introduction: A paucity of in vitro and in vivo models has limited the study of neuroendocrine neoplasms (NENs).

Aim(s): To generate preclinical in vitro models of NENs that can be propagated long-term.

Materials and methods: Building on methods developed in our lab, we have generated patient derived tumor organoids (PDTOs) from low- and high-grade NENs.

Conference: 18th Annual ENETS Concerence (2021)

Presenting Author: Dayton T

Authors: Dayton T, Alcala N, Den Hartigh L, Moonen L, Levy S,

Keywords: organoids, growth factor dependencies, lung NETs,