Abdominal Obesity, Fasting Glucose and Metabolic Syndrome Are Risk Factors for Well Differentiated Digestive Neuroendocrine Tumors

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Introduction: Digestive NETs(DNETs)`s incidence has increased last 40 years. Visceral obesity and metabolic syndrome (MetSyn) were recently reported to be associated with several cancers, although not so far with DNET.

Aim(s): To explore the possible relationship between obesity, MetSyn and well-differentiated(WD) DNETs by undertaking a case-control study.

Materials and methods: Patients with GI-NETs or pNETs(n=96) were recruited from Endocrine Tumors Clinic of IPO Porto and cross-matched with a control group(n=96) derived from the PORMets study, a nationwide epidemiological study that assessed MetSyn prevalence in the general population, pair-matched for age, gender and place of birth. MetSyn was defined using the JIS criteria. DNET were classified according to primary tumor localization, hormonal secretion, TNM stage and WHO grading.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author:

Authors: Santos A, Santos A, Castro C, Raposo L, Torres I,

Keywords: neuroendocrine tumors, metabolic syndrome, visceral obesity ,