Additional Value of New Molecular Imaging Tracers in the Detection of Recurrent/Residual Disease in Patients with Neuroendocrine Tumors

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Introduction: Recent studies have proposed new molecular imaging tracers, such as 18F-DOPA and 68Ga-DOTANOC, for the detection of recurrent/residual neuroendocrine tumors (NET) in case of negative conventional imaging modalities.

Aim(s): To evaluate sensitivity of 18F-DOPA PET/CT and 68Ga-DOTANOC PET/CT in the detection of residual/recurrent NET.

Materials and methods: Fifteen patients with NET were enrolled. All had biochemical evidence of recurrent/residual disease, not evident at conventional imaging techniques. Six patients had medullary thyroid carcinoma (MTC) with post-surgical persistence of increased calcitonin, two had a suspicion of pheocromocytoma, five had SDHB and SDHD mutation gene underlying multiple/malignant polyglandular (PGL) syndrome and two had MEN-1. All patients underwent 18F-DOPA (13 cases) or 68Ga-DOTANOC PET/CT (two cases).

Conference: 10th Annual ENETSConcerence (2013)

Presenting Author:

Authors: Verga U, Filopanti M, Fugazzola L, Rodari M, Lopci E,

Keywords: 18F-DOPA, 68Ga-DOTANOC, recurrent/residual NET,

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