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Adherence to WHO2010 Guideline for Diagnosis of Neuroendocrine Carcinoma and Prognostic Significance


Introduction: Neuroendocrine carcinoma’s (NEC) are diagnosed by a combination of immunohistochemistry (IHC) and morphology according to the 2010 WHO guidelines.

Aim(s): to assess the correctness of NEC diagnosis according to WHO 2010 and to validate prognostic value for overall survival.

Materials and methods: patients registered with a large cell extra pulmonary NEC or extra pulmonary NEC not otherwise specified with the Dutch cancer registry between 2008 and 2012 were included. Pathology was reviewed for morphology and IHC. Patients were correctly diagnosed with a NEC if synaptophysin or chromogranin A was more than 50% positive and MIB or mitotic count confirmed G3 tumor. Overall survival was estimated with Kaplan-Meier and log rank.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author:

Authors: Zandee W, Van der Zwan J, de Herder W, Van Velthuysen L,

Keywords: neuroendocrine carcinoma, IHC, morphology, diagnosis, prognosis, who 2010 ,

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