Affinity Proteomic Plasma Analysis of Human Well-Differentiated Small Intestinal Neuroendocrine Tumors

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Introduction: Small intestine neuroendocrine tumor (SI-NET) patients get diagnosis at the stage of metastasis and there is a lack of curative treatments.

Aim(s): To detect specific, reliable and sensitive biomarker for early diagnosis and disease progression status.

Materials and methods: Human Protein Atlas antibodies (Ab) profiled proteomic signatures from SI-NET blood patients (p) and healthy controls (HC) using an antibody suspension bead array. Untreated patients (153 p) at different stages were divided into two cohorts: cohort 1 (20 HC and 57 p) and cohort 2 (36 HC and 96 p). Markers screening using 188 Ab on cohort 1 selected 20 antigens validated then on cohort 2. Selection was based on univariate and multivariate statistical significance together with the consistency between experiments.

Conference: 10th Annual ENETSConcerence (2013)

Presenting Author: Giandomenico V

Authors: Darmanis S, Cui T, Li S, Öberg K, Nilsson P,

Keywords: small intestine neuroendocrine tumors, blood, antibody-suspension bead-array, biomarker,