Amino acid-induced hyperkalaemia during peptide receptor radionuclide therapy (PRRT): A case report and literature review

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Introduction: PRRT an established treatment for neuroendocrine tumours (NETs). Therapy requires prophylactic positively charged amino acid (AA) co-infusion to reduce renal radiation exposure. AA infusion has been associated with metabolic acidosis and electrolyte abnormalities, particularly hyperkalaemia; comprehensive data on the prevalence and severity of these complications remains limited.

Aim(s): Examining occurrence, risk factors, and management strategies for AA induced metabolic acidosis, hyperkalaemia during PRRT treatment.

Materials and methods: Case report and literature review. Index case 70-year-old patient with multiple comorbidities (DM, IHD, CKD stage 3) who developed severe complications during treatment for progressive PNET.

Conference:

Presenting Author:

Authors: Osher E, Wolf I, Geva R, Sofer Y, Greenman Y,

Keywords: PRRT, hyperkalaemia, amino acid infusion, neuroendocrine tumour, adverse effects,