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Antitumor Efficacy of Temozolomide in Patients with Metastatic Pulmonary Carcinoids


Introduction: Temodal (TMZ) is an oral alternative to dacarbazine.

Aim(s): The aim of this study was to retrospectively analyze the efficacy and safety of TMZ in patients with metastatic pulmonary carcinoids (mPC).

Materials and methods: 34 patients pathologically reviewed mPC according to the WHO criteria, referred to Gustave Roussy from 1993 to 2014 were included. Treatment was given at a dose of 150 mg/m2/day for 5 days (D1=D28), escalated to 200 mg/m2/day if well tolerated. Disease control rate, according to RECIST at 12 months was the primary endpoint. DCR was compared in patients who received both oxaliplatin-based chemotherapy (O-BC) i.e gemox or folfox, and dacarbazine (TMZ or deticene/DTIC-BC) in a subgroup of 16 patients referred to Gustave Roussy or Hospices Civils of Lyon.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author:

Authors: Bello Roufai D, Planchard D, Walter T, Berdelou A, Guigay J,

Keywords: pulmonary carcinoids, temozolomide, safety,

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