Assessment of hormonal levels as prognostic markers and of their optimal cut-offs in small intestinal neuroendocrine tumors grade 2

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Introduction: Multianalytes might be used to monitor small intestinal neuroendocrine tumors (siNETs) Grade 2 in the future, but blood chromogranin A (CgA) and urine 5HIAA are still widely used in clinical praxis.

Aim(s): The aim of this study was to investigate the prognostic value of baseline CgA and 5HIAA at various cut-offs used in literature, and of the early biochemical response to treatment.

Materials and methods: A retrospective cohort study of 184 patients with siNET Grade 2 treated with somatostatin analogues (SSA), interferon-alpha (IFN) or peptide receptor radionuclide therapy (PRRT). CgA and 5HIAA levels were recorded at baseline and at six months and HRs for cancer-specific survival (CSS) and progression-free survival (PFS) were estimated for baseline continuous variables, at 2x, 5x and 10xULN (upper limit of normal) and for six-months changes.

Conference: 18th Annual ENETS Concerence (2021)

Presenting Author:

Authors: Papantoniou D, Grönberg M, Landerholm K, Welin S, Ziolkowska B,

Keywords: Chromogranin A, 5HIAA, small intestinal neuroendocrine tumor, biomarker, carcinoid, cut-offs,