Association between serum biomarkers and liver tumour burden in advanced gastroenteropancreatic neuroendocrine tumours

#4478

Introduction: The association between serum biomarker levels and tumour burden is less studied in GEP-NET.

Aim(s): To evaluate the potential association between serum biomarkers and tumour burden in advanced GEP-NET patients.

Materials and methods: Well-differentiated treatment-naïve GEP-NET patients with liver metastatic disease enrolled. Patients all conducted 68Ga-DOTANOC PET/CT scan and CT scan before initial treatment. Serum liver enzymes (ALT, AST, GGT, LDH, and ALP) and tumour biomarkers (AFP, CEA, CA125, CA199, and NSE) were tested one week before PET/CT scan. Quantitative tumour burden was calculated by 68Ga-DOTANOC PET/CT scan, while semiquantitative liver tumour volume was assessed by CT scan. We calculated Spearman correlations between tumour volume and serum biomarker levels.

Conference:

Presenting Author: Jumai N

Authors: Jumai N, Chen L, Yusufu Y, Yan X, Liu M,

Keywords: Neuroendocrine tumour, tumour burden, prognosis, biomarker,