Blood liver enzyme levels correlate with hepatic tumor burden in advanced neuroendocrine tumors

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Introduction: Abnormal levels of blood liver enzymes, including hepatic liver enzymes alanine aminotransferase (ALT) or aspartate aminotransferase (AST), and cholestatic liver enzymes alkaline phosphatase (ALP) or gamma-glutamyl transpeptidase (GGT)can be found in some patients with advanced neuroendocrine tumors (NETs), but the clinical relevance is less understood.

Aim(s): To explore the role of ALT, AST, ALP and GGT in patients with advanced NETs.

Materials and methods: We retrospectively enrolled patients with advanced NETs. Patients with liver injuries of other causes (such as medication and cholangiectasis) were excluded. Hepatic tumor burden was quantified based on 68Ga-DOTA-NOC PET/CT scan. Serum levels of ALT, AST, ALP and GGT around the time of PET/CT scan were collected. Hepatic tumor burden and levels of liver enzymes were logarithmically transformed (log2[parameter + 1] and log2[parameter], respectively) for statistical analysis.

Conference:

Presenting Author:

Authors: Chen L, Jumai N, Liu M, He Q, Lin Y,

Keywords: neuroendocrine tumor, hepatic tumor burden, liver enzyme, overall survival,