Bone loss and whole-body composition in patients with gastroenteropancreatic neuroendocrine neoplasms

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Introduction: Patients with gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are at increased risk for osteoporosis, but data on muscle and fat mass are scarce.

Aim(s): We cross-sectionally assessed the prevalence of osteoporosis, sarcopenia and fat mass in patients with GEP-NENs.

Materials and methods: We collected data from 41 patients (24 males) (pancreatic NEN: n=14, small-intestine NEN: n=6; gastric NEN (GC) type 1: n=18 and GC3, n=3) who had whole body dual-energy X-ray absorptiometry (DXA). We calculated the appendicular skeletal muscle mass index/height2 ratio (RSMI), bone mineral density (BMD) at the lumbar spine (LS) and hip, total fat mass (TFM) and fat mass ratio (FMR) (trunk fat mass/lower limb fat mass).

Conference:

Presenting Author: Tsoli M

Authors: Aktypis C, Tsoli M, Yavropoulou M, Efstathopoulos E, Kassi E,

Keywords: bone mineral density, osteoporosis, fat mass, sarcopenia, gastroenteropancreatic neoplasm,