BRCA gene mutations and NEN – Is it just random or a meaningful coincidence?

#4168

Introduction: A BRCA mutation denotes a genetic alteration found in either the BRCA1 or BRCA2 genes, both of which function as tumor suppressors. BRCA mutations are widely acknowledged for their link to breast and ovarian cancers, and rarely, to other malignancies such as the pancreas and prostate. Noteworthy, there have been limited reports associating BRCA mutations with NEN, and no possible co-relation to certain racial/ethnic populations has been reported to date.

Aim(s): Evaluating the possible relationship between BRCA and NEN.

Materials and methods: A comprehensive retrospective chart data analysis covering the period from 2013 to 2023 was carried out to identify consecutive patients diagnosed with both BRCA mutations and NEN, to evaluate specific phenotypes and prognostic factors of disease severity.

Conference:

Presenting Author: Bel-Ange A

Authors: Bel-Ange A, Maimon O, Grozinsky-Glasberg S,

Keywords: BRCA gene mutation, NEN-neuroendocrine neoplasm,