Bronchial neuroendocrine tumor

#3157

Introduction: Typical (CT) and atypical (CA) carcinoids are rare tumors that account for 1-2% of all primary bronchial tumors. They are malignant tumors because of their local aggressiveness and metastatic potential.

Aim(s): We report the case of a bronchial neuroendocrine tumor with liver metastases.

Materials and methods: Patient ZB, 29 years old, with no particular history, was referred to us for a lung tumor with hepatic metastases. Following the trans parietal biopsy, the diagnosis of a moderately differentiated lung neuroendocrine tumor of atypical carcinoid type was retained. The liver biopsy confirms the appearance of a secondary localization of a moderately differentiated neuroendocrine tumor type atypical carcinoma of pulmonary origin with chromogranin A and synaptophysin positive immuno-histochemical study. Octoscan shows increased density of somatostatin receptors at the hepatic and pulmonary levels. Serum chromogranin A is very high at 2600 ng/ml since May 2017, a first-line treatment has been introduced with octreotide LP somatostatin analogues at a dose of 30 mg every 28 days. His clinical condition improved under treatment with disappearance of dyspnea and cough and with a sharp regression of lung and liver images on the scanner and a biological decrease of the serum chromogranin A hence the maintenance of the somatostatin analogues to this day.

Conference: 18th Annual ENETS Concerence (2021)

Presenting Author:

Authors: Benamar W, Ghomari-Bezzar S,

Keywords: bronchial neuroendocrine tumor typical (CT) and atypical (CA) carcinoids, liver metastases, differentiated lung neuroendocrine tumor of atypical carcinoid, chromogranin A and synaptophysin, octoscan, serum chromogranine A, octreotide LP,