Chromogranin A as a Tumoral Marker for Neuroendocrine Tumors in Chilean Patients: A Case-Control Study


Introduction: Neuroendocrine tumors (NETs) are highly heterogeneous, serum chromogranin A (CgA) has a 60-100% of sensitivity and 68-100% of specificity with a cutoff value of 108 ng/mL as a marker for diagnosis of NETs.

Aim(s): To assess serum CgA levels in Chilean healthy subjects and NET patients.

Materials and methods: 78 NET patients and 65 healthy subjects were prospectively recruited. Serum CgA levels were measured by ELISA. The Wilcoxon-Mann-Whitney U test was used for comparison of tumor-marker distribution in the study populations. To determine cutoff value, sensitivity, and specificity, area under the curve (AUC) was calculated on receiver operating characteristic (ROC) curve analysis.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author: Munoz Medel M

Authors: Munoz-Medel M, Cordova Delgado M, Pinto M, Bravo M, Retamal I,

Keywords: Neuroendocrine, Chromogranin A, Biomarker,

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