Cisplatin and etoposide as first-line chemotherapy for poorly differentiated neuroendocrine carcinoma of the stomach: A case report

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Introduction: Gastric neuroendocrine tumours (NETs) are rare neoplasms that arise from enterochromaffin cells of the gastric mucosa. Neuroendocrine carcinoma (NEC) of the stomach represent a rare and rapidly growing type of gastric tumour. They are considered a distinct entity from neuroendocrine tumours characterised by aggressive behaviour and a high rate of metastasis.

Aim(s): We report a case of large liver metastasis from a gastric neuroendocrine carcinoma treated in the medical oncology department of the Mostaganem University Hospital Center.

Materials and methods: This is a 54-year-old patient with no particular history, who presented to the medical-surgical emergency department of the Mostaganem University Hospital Center for the management of persistent abdominal pain for 6 months associated with anorexia dating back 20 days with weight loss. The abdominal CT scan revealed a gastric process of the body region of 46 mm with a hepatic mass of 60 mm in diameter located at the level of segment VIII (the abdominal MRI confirmed the secondary nature of this mass). The gastric biopsy was in favour of a neuroendocrine carcinoma associated with a grade 1 neuroendocrine tumour of the stomach with positivity of chromogranin and synaptophysin on immunohistochemistry with Ki-67>20%. The patient was put on palliative chemotherapy type: CDDP etoposide.

Conference:

Presenting Author: Zidane H

Authors: Zidane H, Kebbati Z, Benkada M,

Keywords: neuroendocrine carcinoma, stomach, chemotherapy,