Claudin18.2 expression in gastroenteropancreatic neuroendocrine neoplasms – A clinico-pathologic study

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Introduction: Claudin18.2 is a tight junction protein. Currently, the application of Claudin 18.2 antibody in patients has achieved a great efficacy. However, there are still few systematic studies on the expression of Claudin18.2 in gastroenteropancreatic neuroendocrine neoplasms（GEP-NENs).

Aim(s): In this study, we aimed to explore the clinicopathological features of Claudin18.2 expression in GEP-NENs, and to provide a guidance for clinical research and treatment.

Materials and methods: 292 cases of GEP-NENs, including 141 neuroendocrine tumors (NET) and 151 neuroendocrine cancers (NEC), were stained with Claudin18.2 (14G11) antibody in our center. The staining intensity (weak 1+, medium 2+, strong 3+) and the percentage of positive cells (0-100%) were scored. We defined≥2+ in≥40% of tumor cells membranes intensity as positive.

Conference:

Presenting Author:

Authors: Sun Y, Jiang K, Hu Y, Li J, Lu M,

Keywords: gastroenteropancreatic neuroendocrine neoplasm, claudin18.2, expression,