Co-existing Type-1 Gastric Neuroendocrine Tumors (NETs) and Adenocarcinoma in Autoimmune Associated Atrophic Gastritis


Introduction: Autoimmune gastritis (AIG) causes oxyntic gland atrophy. This condition is often associated with Type-1 gastric NET secondary to achlorhydria and hypergastrinemia. Similar to atrophic gastritis in non-autoimmune conditions, AIG is associated with intestinal metaplasia that could progress to glandular dysplasia.

Aim(s): To delineate the relationship between neuroendocrine cell and glandular epithelium neoplasia.

Materials and methods: We identified 12 cases of AIG with co-existing neuroendocrine cell hyperplasia/NET and glandular neoplasia/adenocarcinoma and characterized pathologic features of both neoplastic processes.

Conference: 9th Annual ENETSConcerence (2012)

Presenting Author:

Authors: Tang L,

Keywords: Type-I gastric NET, gastric adenocarcinoma,

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