Comparison of two prognostic models for the treatment of pancreatic NET with PRRT

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Introduction: The efficacy and time to progression (TTP) following peptide receptor radionuclide therapy (PRRT) for pancreatic neuroendocrine tumours varies widely.

Aim(s): To develop a simple model based on clinical and biochemical factors for predicting TTP after treatment with PRRT.

Materials and methods: We reviewed literature for non-experimental predictors of outcome related to patient status, organ function, inflammation, tumour burden and proliferation. Variables were analysed with an accelerated failure-time model in a previously described cohort of 109 consecutive patients treated at a tertiary centre. The model was bootstrap-validated, and its performance was assessed with Harrell’s c-index and calibration plots. A post-hoc model (derived from the original article’s multivariable analysis) incorporating radiology features, was used for comparison.

Conference:

Presenting Author: Papantoniou D

Authors: Tiensuu Janson E, Fröss-Baron K, Grönberg M, Ziolkowska B,

Keywords: prrt, pancreatic neuroendocrine tumour, predictive model,