Comprehensive genomic and transcriptomic analysis of lung carcinoid reveals molecular differences between typical carcinoid and atypical carcinoid

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Introduction: Typical carcinoids (TCs) and atypical carcinoids (ACs) are two histotypes of lung carcinoids (LCs) exhibiting different prognoses. However, the diagnosis can be difficult for small biopsies. Moreover, the differences in molecular characteristics of the two subtypes lack understanding.

Aim(s): We aimed to characterize the molecular differences between TCs & ACs to aid diagnosis and advance individualized therapy.

Materials and methods: The genomic and transcriptomic data of LCs retrieved from the public database were compared between TCs and ACs. A classification model for TCs and ACs was established based on the genomic parameters using Least Absolute Selection and Shrinkage Operator and Logistic regression.

Conference:

Presenting Author: Guo Y

Authors: Guo Y, Tian C, Cheng Z, Hu S, Chen Q,

Keywords: lung carcinoid, histological subtypes, genomic alteration, transcriptomic difference, drug targets,