Cytoendoscopy for determining the depth of invasion and metastasis of rectal neuroendocrine tumours

#4350

Introduction: Rectal neuroendocrine tumours (rNETs) are relatively common submucosal tumours, but even low-grade rNETs can metastasise. The significance of endocytology (EC) in the clinical evaluation of rNETs has not been reported.

Aim(s): The purpose of this study is to explore the EC characteristics of rNETs (especially crypt structure, nuclear and microvascular morphology), compare them with endoscopic ultrasound (EUS) and imaging results, and observe their diagnostic efficiency for rNETs metastasis. A new scoring system based on EC manifestations is planned to be developed to predict the depth of invasion, metastasis and endoscopic resectability of rNETs.

Materials and methods: A total of 104 patients with rNETs were included in the endoscopic examination. Methylene blue staining was used to observe the characteristics of crypts, cell nuclei, and microvessels in the lesions. An EC scoring system was constructed based on these characteristics. The relationship between the EC score of rNETs and the depth of invasion, metastasis, and endoscopic resectability was analysed.

Conference:

Presenting Author: Tang Q

Authors: Bai J, Tian Y, Tang Q,

Keywords: rectal neuroendocrine tumour, cytoendoscopy, invasion, metastasis, tumour grade,