Dacarbazine- or Temozolomide-Based Chemotherapy in Metastatic Digestive Neuroendocrine Carcinomas in Post First-line Chemotherapy: A Retrospective Multicentric Study of the French Group of Endocrine Tumours (GTE)
Introduction: First-line chemotherapy in metastatic neuroendocrine carcinomas (NEC) is based on etoposide and platinum. However, there is no standard for second line treatment.
Aim(s): The objective of this study was to evaluate efficacy and tolerance of Dacarbazine- or Temozolomide-based chemotherapy in metastatic digestive NEC in post first-line chemotherapy.
Materials and methods: This study included patients with a metastatic NEC of digestive or unknown primary. All of them received platinum-etoposide in first-line chemotherapy. The primary endpoint was progression free survival (PFS). Secondary endpoints were: clinical/biological (ALP decrease >30%)/morphological (RECIST) response, toxicity, and overall survival (OS).
Conference: 17th Annual ENETSConcerence (2020)
Presenting Author: Walter T
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