Defective DNA repair promotes progression of small intestinal neuroendocrine tumours despite a lack of common genomic drivers

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Introduction: The tumorigenesis of small intestinal neuroendocrine tumours (siNETs) is not understood, despite being the most common form of small bowel cancer.

Aim(s): The aim is to unravel the pathogenetic mechanisms of siNETs to understand the crucial steps in the transformation of a healthy neuroendocrine cell into a neuroendocrine tumour cell.

Materials and methods: Therefore, we performed whole genome sequencing of 39 well-differentiated siNETs G1/G2 (primary tumours and metastases) from 32 patients, along with adjacent healthy tissue.

Conference:

Presenting Author: Bolduan F

Authors: Bolduan F, Müller-Bötticher N, Debnath O, Zemojtel T, Kunze C,

Keywords: small intestinal neuroendocrine tumour, pathogenetics, defective DNA repair,