Dissecting the intra- and inter-tumor heterogeneity of adrenocortical carcinoma by single-cell multi-omics analyses

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Introduction: Adrenocortical carcinoma (ACC) is a rare but aggressive malignancy originating in the adrenal cortex, characterized by significant intra- and inter-tumor heterogeneity.

Aim(s): To construct a comprehensive multi-omics landscape of ACC.

Materials and methods: In this study, we conducted comprehensive analyses to decipher the intra- and inter-heterogeneity in ACC, involving whole-genome sequencing (WGS), single-cell RNA (scRNA) sequencing, T-cell receptor (TCR) sequencing, spatial transcriptome sequencing, and multiple fluorescence staining on both normal adrenal tissues and ACC tumors. We thoroughly analyzed the landscapes of the normal adrenal gland and inferred the evolutionary trajectory in adrenal cortex development with the expansion of molecular features.

Conference:

Presenting Author:

Authors: Liu S, Chong C,

Keywords: Adrenocortical carcinoma, immune therapy, tumor heterogeneity,