Dissecting the single-cell transcriptome network underlying thymic neuroendocrine tumor and thymus non-malignant tissues

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Introduction: Thymic neuroendocrine tumor (TNET) is the rarest subtype among thymic epithelial tumors and NET. Limited understanding of tumor microenvironment (TME) of TNET contributes to the lack of treatment options for this rare tumor type.

Aim(s): We aim to conduct a comprehensive analysis of the TME in TNET and to explore potential pathogenesis and therapeutic targets for TNET.

Materials and methods: We performed single-cell RNA sequencing (scRNA) analysis on three tumor specimens and their corresponding non-tumor tissues. Additionally, scRNA data of normal thymic neuroendocrine (NE) cells were retrieved from publicly available databases.

Conference:

Presenting Author: Liu M

Authors: Liu M, Lin X, Chen L, Su C, Wen W,

Keywords: thymic neuroendocrine tumor, single-cell RNA sequencing, tumor microenvironment, tumor-associated fibroblasts,