Dosimetry evaluation in 177Lu-labeled somatostatin analogue therapy

#3342

Introduction: In this paper a dosimetric study of 177Lu-labeled somatostatin analogue (177Lu-DOTATOC) therapy was described.

Aim(s): Comparison of the uptake of radiopharmaceuticals in a diagnostic examination and in therapy. Determination of the therapeutic dose limit based on the SRS study - prospective dosimetry. Dosimetric calculations in therapy with 177Lu-labeled somatostatin analogues - retrospective dosimetry.

Materials and methods: The study included 20 patients treated for neuroendocrine tumors. Reliable post-therapeutic dosimetric calculations were performed in 17 of them. Moreover, in some of them (8 patients) a quantitative analysis of SRS diagnostic images was performed in order to make a priori predictions of the therapeutic dose. The uptake of a diagnostic radiopharmaceutical was compared with the uptake determined in the analysis of therapeutic images. Using the data obtained from the diagnostic examination, the expected dose limit that the patients could receive was determined. Based on the quantitative analysis of post-therapy images in each patient the dose for kidneys, liver and spleen was determined. In patients with clearly distinguished hot spots of radiopharmaceutical accumulation, the dose accumulated in these areas was additionally calculated.

Conference: 18th Annual ENETS Concerence (2021)

Presenting Author:

Authors: Cichoński A, Kempińska Wróbel M, Ćwikła J,

Keywords: internal dosimetry, radioisotope therapy, MIRD,