Effect of different expression status of MGMT on the efficacy of temozolomide in gastroenteropancreatic neuroendocrine tumors

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Introduction: Temozolomide (TMZ) based chemotherapy on gastroenteropancreatic neuroendocrine tumors (GEP-NETs) seems effective, but the predictive effect of 06-methylguanine DNA methyltransferase (MGMT) on efficacy is controversial.

Aim(s): To study the expression of 06-methylguanine DNA methyltransferase (MGMT) in tumor tissues and to explore its effect on the prognosis of gastroenteropancreatic neuroendocrine tumors (GEP-NETs) with TMZ based chemotherapy.

Materials and methods: The tumor tissues of 15 patients with advanced GEP-NETs who received TMZ combined with Tiggio in our hospital from 2017 to 2019 were collected. Immunohistochemistry was used to detect the expression of MGMT protein in the tumor tissues. The progression free survival time (PFS) and drug safety were evaluated and analysed during the follow up period.

Conference: 18th Annual ENETS Concerence (2021)

Presenting Author:

Authors: Li Y, Qi Z, Tan H,

Keywords: neuroendocrine tumor, chemotherapy, MGMT, Temozolomide,