Efficacy of regional and systemic therapies for refractory hypoglycaemia in malignant insulinoma

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Introduction: Insulinoma is a rare neuroendocrine tumour characterised by inappropriate autonomous insulin secretion.

Aim(s): This retrospective review evaluates the efficacy of regional and systemic therapies in managing refractory hypoglycaemia in metastatic or unresectable insulinoma.

Materials and methods: We reviewed patients treated for metastatic or unresectable insulinoma at Mayo Clinic (1992-2024). Hypoglycaemic severity was graded (0=asymptomatic, 1=diet-controlled, 2=requiring meds/procedures, 3=hospitalisation). Surgical interventions (e.g. tumour resection, debulking), regional therapies (e.g. ablation, embolisation), and systemic therapies were assessed for impact on hypoglycaemia.

Conference:

Presenting Author: Koch R

Authors: Koch R, McGarrah P, Eiring R, Hobday T, Halfdanarson T,

Keywords: Insulinoma, radioligand therapy,