Establishing a standardised histopathological grading system for mesenteric fibrosis in small intestinal neuroendocrine tumours

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Introduction: Mesenteric fibrosis (MF) frequently develops around mesenteric metastasis in small intestinal neuroendocrine tumour (SI-NET) patients. Since MF is not always detected radiologically, histopathological examination is considered the gold standard. However, there is no uniform histopathological scoring system for MF correlated with clinical data.

Aim(s): Our aim is to validate a new MF scoring method linked to clinical data

Materials and methods: FFPE blocks of mesenteric metastases from 49 operated SI-NET patients were collagen-stained. MF was graded by analysing the width of the fibrotic capsule, the thickest intratumoural fibrotic band, and the collagen proportional area (CPA) of the tumour mass, both with and without the fibrotic capsule. Staining and digital analysis were performed at two institutions. Additionally, two radiologists conducted a radiological scoring using pre-operative CT scans.

Conference:

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Authors: van der Slik E, Feelders R, Hofland L, Hall A, Iyer A,

Keywords: small intestinal neuroendocrine tumour, mesenteric fibrosis, grading system,